BRD-K39580048_arg-a1-2 BRD-K39580048_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-K39580048_arg-a1-2 BRD-K39580048_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AGO2 argonaute RISC catalytic component 2
AMIGO2 adhesion molecule with Ig-like domain 2
APOC1 apolipoprotein C-I
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
C3ORF52 chromosome 3 open reading frame 52
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CREB3L2 cAMP responsive element binding protein 3-like 2
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
EMX2 empty spiracles homeobox 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FOSL2 FOS-like antigen 2
FZD5 frizzled class receptor 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFNGR1 interferon gamma receptor 1
IGF1R insulin-like growth factor 1 receptor
IL11 interleukin 11
INHBA inhibin, beta A
ITM2C integral membrane protein 2C
JAG1 jagged 1
JUNB jun B proto-oncogene
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED13L mediator complex subunit 13-like
MSX1 msh homeobox 1
MSX2 msh homeobox 2
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NRCAM neuronal cell adhesion molecule
OSER1 oxidative stress responsive serine-rich 1
PAWR PRKC, apoptosis, WT1, regulator
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PFDN4 prefoldin subunit 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PSAT1 phosphoserine aminotransferase 1
PTPRE protein tyrosine phosphatase, receptor type, E
PXDC1 PX domain containing 1
QKI QKI, KH domain containing, RNA binding
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNASET2 ribonuclease T2
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX17 SRY (sex determining region Y)-box 17
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STK38L serine/threonine kinase 38 like
TARS threonyl-tRNA synthetase
TCP1 t-complex 1
THBD thrombomodulin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPM4 tropomyosin 4
TRIB3 tribbles pseudokinase 3
TSC22D2 TSC22 domain family, member 2
TSPAN13 tetraspanin 13
TXNRD1 thioredoxin reductase 1
TYROBP TYRO protein tyrosine kinase binding protein
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADD3 adducin 3 (gamma)
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ANXA6 annexin A6
AOX1 aldehyde oxidase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
C1S complement component 1, s subcomponent
CADPS2 Ca++-dependent secretion activator 2
CBR3 carbonyl reductase 3
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CFH complement factor H
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CTSB cathepsin B
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
EMP3 epithelial membrane protein 3
ERAP2 endoplasmic reticulum aminopeptidase 2
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GOLGA8H golgin A8 family, member H
GSTP1 glutathione S-transferase pi 1
HMGB1 high mobility group box 1
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IGSF3 immunoglobulin superfamily, member 3
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LOXL1 lysyl oxidase-like 1
MAGED1 melanoma antigen family D1
MAPK13 mitogen-activated protein kinase 13
MET MET proto-oncogene, receptor tyrosine kinase
MLANA melan-A
MTMR4 myotubularin related protein 4
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
NISCH nischarin
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM1 olfactomedin 1
PEBP1 phosphatidylethanolamine binding protein 1
PER3 period circadian clock 3
PHF11 PHD finger protein 11
PMEL premelanosome protein
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPAP2B phosphatidic acid phosphatase type 2B
PRDX4 peroxiredoxin 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFTN1 raftlin, lipid raft linker 1
S100A7 S100 calcium binding protein A7
SCARB2 scavenger receptor class B, member 2
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC38A10 solute carrier family 38, member 10
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
STEAP3 STEAP family member 3, metalloreductase
STXBP2 syntaxin binding protein 2
SVIL supervillin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNS1 tensin 1
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
UBE2G2 ubiquitin-conjugating enzyme E2G 2
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZMIZ2 zinc finger, MIZ-type containing 2