BRD-K39580048_arg-a1-2 BRD-K39580048_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K39580048_arg-a1-2 BRD-K39580048_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOC1 apolipoprotein C-I
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GFAP glial fibrillary acidic protein
GPM6B glycoprotein M6B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSER1 oxidative stress responsive serine-rich 1
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PMP2 peripheral myelin protein 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TACSTD2 tumor-associated calcium signal transducer 2
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ASPH aspartate beta-hydroxylase
CADPS2 Ca++-dependent secretion activator 2
CCNF cyclin F
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
FAM13A family with sequence similarity 13, member A
HIST1H4C histone cluster 1, H4c
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MACF1 microtubule-actin crosslinking factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MTDH metadherin
MTERF3 mitochondrial transcription termination factor 3
NPY1R neuropeptide Y receptor Y1
PCGF2 polycomb group ring finger 2
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PTGER3 prostaglandin E receptor 3 (subtype EP3)
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
STC1 stanniocalcin 1