BRD-K39484304_triptolide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K39484304_triptolide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ANXA11 annexin A11
ARG2 arginase 2
C10ORF10 chromosome 10 open reading frame 10
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ESM1 endothelial cell-specific molecule 1
ESRP1 epithelial splicing regulatory protein 1
EXPH5 exophilin 5
FABP7 fatty acid binding protein 7, brain
FAM198B family with sequence similarity 198, member B
FHOD3 formin homology 2 domain containing 3
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT1 fms-related tyrosine kinase 1
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GLO1 glyoxalase I
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOMER2 homer scaffolding protein 2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
LAPTM5 lysosomal protein transmembrane 5
LRRC17 leucine rich repeat containing 17
LTA4H leukotriene A4 hydrolase
LUM lumican
MEF2C myocyte enhancer factor 2C
MXRA5 matrix-remodelling associated 5
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
ORM1 orosomucoid 1
P3H2 prolyl 3-hydroxylase 2
PBX3 pre-B-cell leukemia homeobox 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA3 protein disulfide isomerase family A, member 3
PLS3 plastin 3
PRDX2 peroxiredoxin 2
PRKCI protein kinase C, iota
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
PTTG1IP pituitary tumor-transforming 1 interacting protein
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS5 ribosomal protein S5
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX7 sorting nexin 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TGFB3 transforming growth factor, beta 3
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VWA5A von Willebrand factor A domain containing 5A
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHR aryl hydrocarbon receptor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BRPF1 bromodomain and PHD finger containing, 1
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CRY1 cryptochrome circadian clock 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP3 epithelial membrane protein 3
ERF Ets2 repressor factor
ETV5 ets variant 5
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM208B family with sequence similarity 208, member B
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GEMIN4 gem (nuclear organelle) associated protein 4
GGNBP2 gametogenetin binding protein 2
GRWD1 glutamate-rich WD repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSPA14 heat shock 70kDa protein 14
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANSL2 KAT8 regulatory NSL complex subunit 2
KLF10 Kruppel-like factor 10
KRT7 keratin 7, type II
KYNU kynureninase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MFSD5 major facilitator superfamily domain containing 5
MTPAP mitochondrial poly(A) polymerase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NPAS2 neuronal PAS domain protein 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDS5B PDS5 cohesin associated factor B
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PLAGL2 pleiomorphic adenoma gene-like 2
POU2AF1 POU class 2 associating factor 1
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKD2 protein kinase D2
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEC24A SEC24 family member A
SETD5 SET domain containing 5
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMOX spermine oxidase
SNX11 sorting nexin 11
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TESC tescalcin
TEX10 testis expressed 10
TFB2M transcription factor B2, mitochondrial
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM243 transmembrane protein 243, mitochondrial
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAF4 TNF receptor-associated factor 4
TRIM32 tripartite motif containing 32
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
TXNL4B thioredoxin-like 4B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCPKMT valosin containing protein lysine (K) methyltransferase
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBTB38 zinc finger and BTB domain containing 38
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM2 zinc finger, MYM-type 2
ZNF330 zinc finger protein 330