BRD-K39345836_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K39345836_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
C5AR1 complement component 5a receptor 1
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELOVL5 ELOVL fatty acid elongase 5
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
JUN jun proto-oncogene
LPL lipoprotein lipase
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPIF peptidylprolyl isomerase F
PTGES prostaglandin E synthase
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC16A6 solute carrier family 16, member 6
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SQSTM1 sequestosome 1
TBP TATA box binding protein
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ANGPT1 angiopoietin 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CCNB1 cyclin B1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL1A2 collagen, type I, alpha 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FLRT3 fibronectin leucine rich transmembrane protein 3
HOPX HOP homeobox
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
LYZ lysozyme
MMP12 matrix metallopeptidase 12
NOV nephroblastoma overexpressed
PEG10 paternally expressed 10
POSTN periostin, osteoblast specific factor
RGS2 regulator of G-protein signaling 2
SEPP1 selenoprotein P, plasma, 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNS3 tensin 3