BRD-K39256324_Rottlerin_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K39256324_Rottlerin_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECM1 extracellular matrix protein 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FNDC3B fibronectin type III domain containing 3B
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPM6B glycoprotein M6B
GSDMB gasdermin B
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INHBE inhibin, beta E
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NIT1 nitrilase 1
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC3 serine incorporator 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
TARS threonyl-tRNA synthetase
TRIB3 tribbles pseudokinase 3
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CRYZ crystallin, zeta (quinone reductase)
DCK deoxycytidine kinase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP2 epithelial membrane protein 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HOXA10 homeobox A10
HOXC6 homeobox C6
IRX5 iroquois homeobox 5
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MSH6 mutS homolog 6
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMC4 structural maintenance of chromosomes 4
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TMEM97 transmembrane protein 97
TMF1 TATA element modulatory factor 1
TNC tenascin C
TRIM28 tripartite motif containing 28
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein