BRD-K39120595_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K39120595_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMOTL2 angiomotin like 2
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHN2 chimerin 2
CTSK cathepsin K
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHA2 EPH receptor A2
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GTF2IRD1 GTF2I repeat domain containing 1
HOMER3 homer scaffolding protein 3
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
ITGB4 integrin, beta 4
KRT81 keratin 81, type II
LAMA5 laminin, alpha 5
LXN latexin
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NCAM1 neural cell adhesion molecule 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PFKM phosphofructokinase, muscle
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PRAF2 PRA1 domain family, member 2
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC2 stanniocalcin 2
TES testin LIM domain protein
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPP1 tripeptidyl peptidase I
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AK1 adenylate kinase 1
ANGPT1 angiopoietin 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK6 cyclin-dependent kinase 6
CPNE3 copine III
CRYZ crystallin, zeta (quinone reductase)
CTTN cortactin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELAVL1 ELAV like RNA binding protein 1
FAM46A family with sequence similarity 46, member A
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF14 kinesin family member 14
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
OLFM1 olfactomedin 1
PCNA proliferating cell nuclear antigen
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRPF4B pre-mRNA processing factor 4B
RAB14 RAB14, member RAS oncogene family
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPTSSA serine palmitoyltransferase, small subunit A
STRA13 stimulated by retinoic acid 13
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMED2 transmembrane emp24 domain trafficking protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
VCAN versican
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZWILCH zwilch kinetochore protein