BRD-K39111395_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K39111395_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CALD1 caldesmon 1
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CREB1 cAMP responsive element binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
FAM129A family with sequence similarity 129, member A
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP6 insulin-like growth factor binding protein 6
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KRT19 keratin 19, type I
LSP1 lymphocyte-specific protein 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
BEX1 brain expressed, X-linked 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CHRDL1 chordin-like 1
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FGF13 fibroblast growth factor 13
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IGFBP5 insulin-like growth factor binding protein 5
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
MAGEA3 melanoma antigen family A3
MAN1C1 mannosidase, alpha, class 1C, member 1
MECOM MDS1 and EVI1 complex locus
MOK MOK protein kinase
MT1X metallothionein 1X
NR2F2 nuclear receptor subfamily 2, group F, member 2
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SFRP1 secreted frizzled-related protein 1
SH3BP4 SH3-domain binding protein 4
SPTBN1 spectrin, beta, non-erythrocytic 1
STC1 stanniocalcin 1
STOM stomatin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TFDP1 transcription factor Dp-1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNC tenascin C
TNS3 tensin 3
VSNL1 visinin-like 1