BRD-K38634661_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K38634661_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CAPN2 calpain 2, (m/II) large subunit
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
CPM carboxypeptidase M
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
EGR1 early growth response 1
EGR3 early growth response 3
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GPM6B glycoprotein M6B
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLK10 kallikrein-related peptidase 10
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
MXI1 MAX interactor 1, dimerization protein
NOTCH2NL notch 2 N-terminal like
OLFM4 olfactomedin 4
PLTP phospholipid transfer protein
PRELP proline/arginine-rich end leucine-rich repeat protein
RAB20 RAB20, member RAS oncogene family
RND3 Rho family GTPase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLIT2 slit homolog 2 (Drosophila)
SORD sorbitol dehydrogenase
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
APOA1 apolipoprotein A-I
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
LAP3 leucine aminopeptidase 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYRF myelin regulatory factor
NTS neurotensin
PCOLCE2 procollagen C-endopeptidase enhancer 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TNNT1 troponin T type 1 (skeletal, slow)