BRD-K38615104_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

346 genes differentially expressed following the BRD-K38615104_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
BAG6 BCL2-associated athanogene 6
BLNK B-cell linker
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ETHE1 ethylmalonic encephalopathy 1
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT1 fms-related tyrosine kinase 1
FST follistatin
FSTL1 follistatin-like 1
GPM6A glycoprotein M6A
GPX1 glutathione peroxidase 1
GSTA4 glutathione S-transferase alpha 4
GUK1 guanylate kinase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA0226L KIAA0226-like
KLK8 kallikrein-related peptidase 8
LHFP lipoma HMGIC fusion partner
LOXL2 lysyl oxidase-like 2
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFML2A olfactomedin-like 2A
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRAME preferentially expressed antigen in melanoma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRTN3 proteinase 3
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGCE sarcoglycan, epsilon
SH3BGR SH3 domain binding glutamate-rich protein
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TCF4 transcription factor 4
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
VIM vimentin
WWC3 WWC family member 3
XAF1 XIAP associated factor 1
ZNF532 zinc finger protein 532
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTN1 actinin, alpha 1
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX6 armadillo repeat containing, X-linked 6
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CCDC59 coiled-coil domain containing 59
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CEP350 centrosomal protein 350kDa
CEP76 centrosomal protein 76kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLP1 cleavage and polyadenylation factor I subunit 1
COIL coilin
CST1 cystatin SN
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FADD Fas (TNFRSF6)-associated via death domain
FBXO34 F-box protein 34
FEN1 flap structure-specific endonuclease 1
FOXA1 forkhead box A1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2B general transcription factor IIB
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGKV4-1 immunoglobulin kappa variable 4-1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT17 keratin 17, type I
KYNU kynureninase
LIPT1 lipoyltransferase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
METTL18 methyltransferase like 18
MFSD5 major facilitator superfamily domain containing 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOTCH2NL notch 2 N-terminal like
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDS5B PDS5 cohesin associated factor B
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRR7 proline rich 7 (synaptic)
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSPC1 paraspeckle component 1
PTRH2 peptidyl-tRNA hydrolase 2
RABIF RAB interacting factor
RAE1 ribonucleic acid export 1
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RIOK2 RIO kinase 2
RNF113A ring finger protein 113A
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SCAF8 SR-related CTD-associated factor 8
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPHS2 selenophosphate synthetase 2
SERTAD3 SERTA domain containing 3
SESN1 sestrin 1
SFN stratifin
SIAH2 siah E3 ubiquitin protein ligase 2
SIX1 SIX homeobox 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SOCS1 suppressor of cytokine signaling 1
SOX4 SRY (sex determining region Y)-box 4
SPATA2 spermatogenesis associated 2
STC2 stanniocalcin 2
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBPL1 TBP-like 1
TBX2 T-box 2
TEFM transcription elongation factor, mitochondrial
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
THAP11 THAP domain containing 11
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK2 tousled-like kinase 2
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
VCPKMT valosin containing protein lysine (K) methyltransferase
VEZF1 vascular endothelial zinc finger 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBED5 zinc finger, BED-type containing 5
ZBTB1 zinc finger and BTB domain containing 1
ZBTB11 zinc finger and BTB domain containing 11
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF217 zinc finger protein 217
ZNF263 zinc finger protein 263
ZNF267 zinc finger protein 267
ZNF443 zinc finger protein 443
ZNF574 zinc finger protein 574
ZNF652 zinc finger protein 652