BRD-K38615104_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K38615104_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
ARG2 arginase 2
ASPN asporin
BMP2 bone morphogenetic protein 2
BSG basigin (Ok blood group)
C1QA complement component 1, q subcomponent, A chain
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CFD complement factor D (adipsin)
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FBXL7 F-box and leucine-rich repeat protein 7
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
INA internexin neuronal intermediate filament protein, alpha
INSM1 insulinoma-associated 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2B integral membrane protein 2B
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
PAX6 paired box 6
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PRTN3 proteinase 3
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SNX7 sorting nexin 7
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABLIM1 actin binding LIM protein 1
AKR1C3 aldo-keto reductase family 1, member C3
ANXA5 annexin A5
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BCAS3 breast carcinoma amplified sequence 3
CALML4 calmodulin-like 4
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CLTC clathrin, heavy chain (Hc)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ESR1 estrogen receptor 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
KDM5D lysine (K)-specific demethylase 5D
KIAA0391 KIAA0391
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
KYNU kynureninase
LTF lactotransferrin
LXN latexin
MANSC1 MANSC domain containing 1
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MRPS30 mitochondrial ribosomal protein S30
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PFKP phosphofructokinase, platelet
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROM1 prominin 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RAE1 ribonucleic acid export 1
RFK riboflavin kinase
RNASE4 ribonuclease, RNase A family, 4
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TMEM251 transmembrane protein 251
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
XBP1 X-box binding protein 1