BRD-K38615104_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

239 genes differentially expressed following the BRD-K38615104_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANGPTL2 angiopoietin-like 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BLNK B-cell linker
CA2 carbonic anhydrase II
CA9 carbonic anhydrase IX
CD24 CD24 molecule
CKB creatine kinase, brain
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FAM149A family with sequence similarity 149, member A
FAM198B family with sequence similarity 198, member B
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOXF1 forkhead box F1
GPM6A glycoprotein M6A
GRN granulin
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2AFY H2A histone family, member Y
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
ITM2A integral membrane protein 2A
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA0226L KIAA0226-like
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NRP1 neuropilin 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
PCP4 Purkinje cell protein 4
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SOX11 SRY (sex determining region Y)-box 11
SSPN sarcospan
SST somatostatin
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
TCF21 transcription factor 21
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TRHDE thyrotropin-releasing hormone degrading enzyme
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADGRG2 adhesion G protein-coupled receptor G2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4A ADP-ribosylation factor-like 4A
ARMCX6 armadillo repeat containing, X-linked 6
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDR2 cerebellar degeneration-related protein 2, 62kDa
CENPA centromere protein A
CENPN centromere protein N
CHIC2 cysteine-rich hydrophobic domain 2
CHPT1 choline phosphotransferase 1
COASY CoA synthase
CORO1C coronin, actin binding protein, 1C
CRY1 cryptochrome circadian clock 1
CTNND1 catenin (cadherin-associated protein), delta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EED embryonic ectoderm development
EHD1 EH-domain containing 1
FBXO7 F-box protein 7
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIAA0391 KIAA0391
KIF14 kinesin family member 14
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LMNA lamin A/C
LPAR1 lysophosphatidic acid receptor 1
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MEPCE methylphosphate capping enzyme
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MMP7 matrix metallopeptidase 7
MRPL15 mitochondrial ribosomal protein L15
MRPS12 mitochondrial ribosomal protein S12
MRPS31 mitochondrial ribosomal protein S31
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDCD10 programmed cell death 10
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PHF20 PHD finger protein 20
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRPF4 pre-mRNA processing factor 4
RAB14 RAB14, member RAS oncogene family
RANBP2 RAN binding protein 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RGS1 regulator of G-protein signaling 1
RIT1 Ras-like without CAAX 1
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SCO2 SCO2 cytochrome c oxidase assembly protein
SFN stratifin
SIX2 SIX homeobox 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEFM transcription elongation factor, mitochondrial
TES testin LIM domain protein
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TOB2 transducer of ERBB2, 2
TRIM29 tripartite motif containing 29
TSC22D1 TSC22 domain family, member 1
TSPYL4 TSPY-like 4
TXNDC9 thioredoxin domain containing 9
UGCG UDP-glucose ceramide glucosyltransferase
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VGLL4 vestigial-like family member 4
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF146 zinc finger protein 146