BRD-K38340366_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K38340366_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AFP alpha-fetoprotein
ALB albumin
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CAV2 caveolin 2
CRP C-reactive protein, pentraxin-related
CSRP2 cysteine and glycine-rich protein 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMP3 epithelial membrane protein 3
FOSL1 FOS-like antigen 1
FST follistatin
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HP haptoglobin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NNMT nicotinamide N-methyltransferase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
SDC2 syndecan 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPST2 tyrosylprotein sulfotransferase 2
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
U2AF1 U2 small nuclear RNA auxiliary factor 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CDK1 cyclin-dependent kinase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOSL2 FOS-like antigen 2
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GNPDA1 glucosamine-6-phosphate deaminase 1
GREB1 growth regulation by estrogen in breast cancer 1
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
HSPH1 heat shock 105kDa/110kDa protein 1
KIAA0101 KIAA0101
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
MSMB microseminoprotein, beta-
NET1 neuroepithelial cell transforming 1
NOV nephroblastoma overexpressed
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PRSS23 protease, serine, 23
PRSS8 protease, serine, 8
PTGES prostaglandin E synthase
QPCT glutaminyl-peptide cyclotransferase
RBM47 RNA binding motif protein 47
RNASE4 ribonuclease, RNase A family, 4
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SLC16A4 solute carrier family 16, member 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMC2 structural maintenance of chromosomes 2
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TM9SF2 transmembrane 9 superfamily member 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM135 transmembrane protein 135
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TPD52L1 tumor protein D52-like 1
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VLDLR very low density lipoprotein receptor
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein