BRD-K37991163_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K37991163_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1C2 aldo-keto reductase family 1, member C2
AMACR alpha-methylacyl-CoA racemase
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CALR calreticulin
CES1 carboxylesterase 1
CLDN3 claudin 3
CNPY3 canopy FGF signaling regulator 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
EML3 echinoderm microtubule associated protein like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO3 forkhead box O3
GREM1 gremlin 1, DAN family BMP antagonist
H2AFV H2A histone family, member V
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HYOU1 hypoxia up-regulated 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGSF3 immunoglobulin superfamily, member 3
KIAA1598
LY75 lymphocyte antigen 75
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1 PDZ domain containing 1
PER1 period circadian clock 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRSS21 protease, serine, 21 (testisin)
PRSS8 protease, serine, 8
RAB17 RAB17, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RNMT RNA (guanine-7-) methyltransferase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERINC5 serine incorporator 5
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
SORBS3 sorbin and SH3 domain containing 3
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
TNS1 tensin 1
TNS3 tensin 3
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ATF3 activating transcription factor 3
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CLTB clathrin, light chain B
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
FAIM Fas apoptotic inhibitory molecule
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FST follistatin
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX1 glutathione peroxidase 1
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
KRT13 keratin 13, type I
KRT5 keratin 5, type II
MEIS2 Meis homeobox 2
MIA melanoma inhibitory activity
MMP7 matrix metallopeptidase 7
MYBPC1 myosin binding protein C, slow type
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PNP purine nucleoside phosphorylase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC35G2 solute carrier family 35, member G2
SPRR3 small proline-rich protein 3
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TPM1 tropomyosin 1 (alpha)
TRIB2 tribbles pseudokinase 2
TSPO translocator protein (18kDa)
TUBB2A tubulin, beta 2A class IIa
U2AF1 U2 small nuclear RNA auxiliary factor 1
VCL vinculin