BRD-K37865504_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

221 genes differentially expressed following the BRD-K37865504_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
ANXA1 annexin A1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CNN3 calponin 3, acidic
CSRP1 cysteine and glycine-rich protein 1
CTTN cortactin
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FILIP1L filamin A interacting protein 1-like
FLT3 fms-related tyrosine kinase 3
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FXYD5 FXYD domain containing ion transport regulator 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA2 heat shock 70kDa protein 2
IGHM immunoglobulin heavy constant mu
IL6ST interleukin 6 signal transducer
ILK integrin-linked kinase
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB6 integrin, beta 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KYNU kynureninase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MCTP1 multiple C2 domains, transmembrane 1
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MMP7 matrix metallopeptidase 7
MSRA methionine sulfoxide reductase A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAV2 neuron navigator 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NUPR1 nuclear protein, transcriptional regulator, 1
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2C phosphatidic acid phosphatase type 2C
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
RAB32 RAB32, member RAS oncogene family
S100A10 S100 calcium binding protein A10
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORBS2 sorbin and SH3 domain containing 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
WBP2 WW domain binding protein 2
XIST X inactive specific transcript (non-protein coding)
ZYX zyxin

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP7 A kinase (PRKA) anchor protein 7
ASCL1 achaete-scute family bHLH transcription factor 1
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CCL4 chemokine (C-C motif) ligand 4
CCNA2 cyclin A2
CD69 CD69 molecule
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COL3A1 collagen, type III, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSL cathepsin L
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
FOXF1 forkhead box F1
FRZB frizzled-related protein
FZD7 frizzled class receptor 7
GALC galactosylceramidase
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPC3 glypican 3
GREB1 growth regulation by estrogen in breast cancer 1
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
IGFBP3 insulin-like growth factor binding protein 3
ILF3 interleukin enhancer binding factor 3, 90kDa
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ISL1 ISL LIM homeobox 1
ITGB5 integrin, beta 5
IVNS1ABP influenza virus NS1A binding protein
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LUM lumican
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MEIS1 Meis homeobox 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH10 myosin, heavy chain 10, non-muscle
NAE1 NEDD8 activating enzyme E1 subunit 1
NDN necdin, melanoma antigen (MAGE) family member
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAGL1 pleiomorphic adenoma gene-like 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PTCH1 patched 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBBP4 retinoblastoma binding protein 4
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REC8 REC8 meiotic recombination protein
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SET SET nuclear proto-oncogene
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TIMELESS timeless circadian clock
TMEM100 transmembrane protein 100
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
VCAM1 vascular cell adhesion molecule 1
VCAN versican
ZWINT ZW10 interacting kinetochore protein