BRD-K37865504_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K37865504_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ACTN1 actinin, alpha 1
ADM adrenomedullin
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
BMP4 bone morphogenetic protein 4
C1ORF106 chromosome 1 open reading frame 106
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCHS1 dachsous cadherin-related 1
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FSCN1 fascin actin-bundling protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GPR161 G protein-coupled receptor 161
HBEGF heparin-binding EGF-like growth factor
HIC2 hypermethylated in cancer 2
INHBB inhibin, beta B
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL2 lysyl oxidase-like 2
MAP1B microtubule-associated protein 1B
MEIS2 Meis homeobox 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
NEB nebulin
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PAWR PRKC, apoptosis, WT1, regulator
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RNF19B ring finger protein 19B
RTN2 reticulon 2
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
TAGLN transgelin
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
ZYX zyxin

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ARMCX2 armadillo repeat containing, X-linked 2
B3GNT1
C14ORF1 chromosome 14 open reading frame 1
C1S complement component 1, s subcomponent
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CHPT1 choline phosphotransferase 1
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
ESR1 estrogen receptor 1
FAM111A family with sequence similarity 111, member A
FAM63A family with sequence similarity 63, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HLTF helicase-like transcription factor
HOXC10 homeobox C10
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRX5 iroquois homeobox 5
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGED1 melanoma antigen family D1
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MOAP1 modulator of apoptosis 1
MUC1 mucin 1, cell surface associated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCD protein kinase C, delta
PTGES prostaglandin E synthase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM38B transmembrane protein 38B
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRAPPC4 trafficking protein particle complex 4
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1