BRD-K37764012_PF-3758309_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

282 genes differentially expressed following the BRD-K37764012_PF-3758309_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRG6 adhesion G protein-coupled receptor G6
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD10 ankyrin repeat domain 10
APOLD1 apolipoprotein L domain containing 1
ARFIP2 ADP-ribosylation factor interacting protein 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
C9ORF3 chromosome 9 open reading frame 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTSA cathepsin A
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EMC3 ER membrane protein complex subunit 3
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
ETNK1 ethanolamine kinase 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM134A family with sequence similarity 134, member A
FAM46A family with sequence similarity 46, member A
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FNBP1 formin binding protein 1
GOLM1 golgi membrane protein 1
GPC3 glypican 3
GPC4 glypican 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HCCS holocytochrome c synthase
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM3 intercellular adhesion molecule 3
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA7 integrin, alpha 7
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM2A lysine (K)-specific demethylase 2A
KIAA0125 KIAA0125
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LMOD1 leiomodin 1 (smooth muscle)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS1 Meis homeobox 1
MFSD10 major facilitator superfamily domain containing 10
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NR2C1 nuclear receptor subfamily 2, group C, member 1
NXN nucleoredoxin
OPTN optineurin
OSMR oncostatin M receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PI3 peptidase inhibitor 3, skin-derived
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNMA1 paraneoplastic Ma antigen 1
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAB9A RAB9A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RNF11 ring finger protein 11
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SEPT6 septin 6
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFTPA2 surfactant protein A2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STK39 serine threonine kinase 39
TGM2 transglutaminase 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TSTA3 tissue specific transplantation antigen P35B
UBE3B ubiquitin protein ligase E3B
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
XPO7 exportin 7
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APMAP adipocyte plasma membrane associated protein
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL4 chemokine (C-C motif) ligand 4
CCNA2 cyclin A2
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CISH cytokine inducible SH2-containing protein
CKS1B CDC28 protein kinase regulatory subunit 1B
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
COPS7A COP9 signalosome subunit 7A
CREB1 cAMP responsive element binding protein 1
CST7 cystatin F (leukocystatin)
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV1 ets variant 1
FAM3C family with sequence similarity 3, member C
FAP fibroblast activation protein, alpha
FBXO5 F-box protein 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FKBP5 FK506 binding protein 5
FST follistatin
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGN2 high mobility group nucleosomal binding domain 2
HNMT histamine N-methyltransferase
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KRT23 keratin 23, type I
LMNB1 lamin B1
LMO4 LIM domain only 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MSH6 mutS homolog 6
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAV3 neuron navigator 3
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NTS neurotensin
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PEA15 phosphoprotein enriched in astrocytes 15
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPIE peptidylprolyl isomerase E (cyclophilin E)
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
RAD21 RAD21 homolog (S. pombe)
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RCC1 regulator of chromosome condensation 1
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
TUBB tubulin, beta class I
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VCAN versican
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VTCN1 V-set domain containing T cell activation inhibitor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)