BRD-K37764012_PF-3758309_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K37764012_PF-3758309_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
ANXA4 annexin A4
ARFIP2 ADP-ribosylation factor interacting protein 2
BASP1 brain abundant, membrane attached signal protein 1
BSG basigin (Ok blood group)
CCDC92 coiled-coil domain containing 92
CCND1 cyclin D1
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC5 chloride intracellular channel 5
COL4A1 collagen, type IV, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHCR24 24-dehydrocholesterol reductase
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSP desmoplakin
DUSP3 dual specificity phosphatase 3
EFNB2 ephrin-B2
ETNK1 ethanolamine kinase 1
FAM65B family with sequence similarity 65, member B
FHL1 four and a half LIM domains 1
FNBP1 formin binding protein 1
FOXJ3 forkhead box J3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
H2BFS H2B histone family, member S (pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFT20 intraflagellar transport 20
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
ITM2C integral membrane protein 2C
KDM5B lysine (K)-specific demethylase 5B
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGMN legumain
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXI1 MAX interactor 1, dimerization protein
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
OPTN optineurin
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDE4D phosphodiesterase 4D, cAMP-specific
PEG10 paternally expressed 10
PFKP phosphofructokinase, platelet
PI3 peptidase inhibitor 3, skin-derived
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PON2 paraoxonase 2
PRKCB protein kinase C, beta
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL39L ribosomal protein L39-like
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SCRN1 secernin 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SEPT6 septin 6
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STK39 serine threonine kinase 39
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TRIM36 tripartite motif containing 36
TSPAN1 tetraspanin 1
TUFT1 tuftelin 1
UGDH UDP-glucose 6-dehydrogenase
VCL vinculin
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ANO1 anoctamin 1, calcium activated chloride channel
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP9 aquaporin 9
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BLMH bleomycin hydrolase
C7 complement component 7
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CD14 CD14 molecule
CDC42 cell division cycle 42
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CFI complement factor I
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CRTAP cartilage associated protein
CTSH cathepsin H
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ETV1 ets variant 1
EXOSC8 exosome component 8
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GRB14 growth factor receptor-bound protein 14
GSTZ1 glutathione S-transferase zeta 1
GTSE1 G-2 and S-phase expressed 1
HBB hemoglobin, beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNMT histamine N-methyltransferase
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPL heterogeneous nuclear ribonucleoprotein L
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LMNB1 lamin B1
LMO4 LIM domain only 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MECOM MDS1 and EVI1 complex locus
MELK maternal embryonic leucine zipper kinase
NDRG2 NDRG family member 2
NES nestin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUSAP1 nucleolar and spindle associated protein 1
PALMD palmdelphin
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PLAUR plasminogen activator, urokinase receptor
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RFC3 replication factor C (activator 1) 3, 38kDa
RPA3 replication protein A3, 14kDa
RPL36AL ribosomal protein L36a-like
RPS6 ribosomal protein S6
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SRPX sushi-repeat containing protein, X-linked
SRSF3 serine/arginine-rich splicing factor 3
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STEAP3 STEAP family member 3, metalloreductase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
THBD thrombomodulin
TIPIN TIMELESS interacting protein
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM24 tripartite motif containing 24
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1