BRD-K37764012_PF-3758309_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K37764012_PF-3758309_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRG2 adhesion G protein-coupled receptor G2
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOA aldolase A, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
CTGF connective tissue growth factor
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CYR61 cysteine-rich, angiogenic inducer, 61
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPP4 dipeptidyl-peptidase 4
DUSP5 dual specificity phosphatase 5
FGG fibrinogen gamma chain
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GOLM1 golgi membrane protein 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
INHBB inhibin, beta B
IRF7 interferon regulatory factor 7
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MX2 MX dynamin-like GTPase 2
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
OPTN optineurin
OSBPL10 oxysterol binding protein-like 10
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POSTN periostin, osteoblast specific factor
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIC peptidylprolyl isomerase C (cyclophilin C)
QPCT glutaminyl-peptide cyclotransferase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STOM stomatin
SVIL supervillin
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP1 topoisomerase (DNA) I
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSTA3 tissue specific transplantation antigen P35B
UFM1 ubiquitin-fold modifier 1
VCL vinculin
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATAD2 ATPase family, AAA domain containing 2
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
C20ORF27 chromosome 20 open reading frame 27
C7 complement component 7
CALR calreticulin
CCNA2 cyclin A2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CLC Charcot-Leyden crystal galectin
COTL1 coactosin-like F-actin binding protein 1
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DOK5 docking protein 5
ELANE elastase, neutrophil expressed
ESRP1 epithelial splicing regulatory protein 1
FABP7 fatty acid binding protein 7, brain
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HAL histidine ammonia-lyase
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KANK1 KN motif and ankyrin repeat domains 1
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
MATN2 matrilin 2
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MFSD10 major facilitator superfamily domain containing 10
MLANA melan-A
MRPL19 mitochondrial ribosomal protein L19
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAP1L1 nucleosome assembly protein 1-like 1
NREP neuronal regeneration related protein
PBX2 pre-B-cell leukemia homeobox 2
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PSAT1 phosphoserine aminotransferase 1
PSRC1 proline/serine-rich coiled-coil 1
RAD54B RAD54 homolog B (S. cerevisiae)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A6 S100 calcium binding protein A6
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
STMN1 stathmin 1
THYN1 thymocyte nuclear protein 1
TMEM47 transmembrane protein 47
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZIC1 Zic family member 1
ZWINT ZW10 interacting kinetochore protein