BRD-K37764012_PF-3758309_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K37764012_PF-3758309_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ANKRD10 ankyrin repeat domain 10
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP9A ATPase, class II, type 9A
BCL2L1 BCL2-like 1
CCDC176 coiled-coil domain containing 176
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CTGF connective tissue growth factor
CTSA cathepsin A
CXCL13 chemokine (C-X-C motif) ligand 13
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EZR ezrin
FCGBP Fc fragment of IgG binding protein
FUCA1 fucosidase, alpha-L- 1, tissue
GALC galactosylceramidase
GOLGA8H golgin A8 family, member H
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INHBB inhibin, beta B
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KRT18 keratin 18, type I
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
MACF1 microtubule-actin crosslinking factor 1
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MVP major vault protein
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PSENEN presenilin enhancer gamma secretase subunit
QPCT glutaminyl-peptide cyclotransferase
RBKS ribokinase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SDC4 syndecan 4
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
TCTA T-cell leukemia translocation altered
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TSPAN1 tetraspanin 1
TUFT1 tuftelin 1
VCL vinculin
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
XK X-linked Kx blood group

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AK4 adenylate kinase 4
ATF5 activating transcription factor 5
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BARD1 BRCA1 associated RING domain 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CEP57 centrosomal protein 57kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESRP1 epithelial splicing regulatory protein 1
FAM64A family with sequence similarity 64, member A
FOXM1 forkhead box M1
FST follistatin
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GTSE1 G-2 and S-phase expressed 1
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
IGFBP4 insulin-like growth factor binding protein 4
IL7R interleukin 7 receptor
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
LBR lamin B receptor
LMNB1 lamin B1
LTF lactotransferrin
MCM4 minichromosome maintenance complex component 4
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
PHGDH phosphoglycerate dehydrogenase
PIP prolactin-induced protein
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSRC1 proline/serine-rich coiled-coil 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RCC1 regulator of chromosome condensation 1
RFC2 replication factor C (activator 1) 2, 40kDa
RHOBTB3 Rho-related BTB domain containing 3
RNF130 ring finger protein 130
RNH1 ribonuclease/angiogenin inhibitor 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SERINC5 serine incorporator 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMC4 structural maintenance of chromosomes 4
SNX10 sorting nexin 10
SORBS2 sorbin and SH3 domain containing 2
SPC25 SPC25, NDC80 kinetochore complex component
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STMN1 stathmin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THAP11 THAP domain containing 11
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TWIST1 twist family bHLH transcription factor 1
UBE2C ubiquitin-conjugating enzyme E2C
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF22 zinc finger protein 22