BRD-K37764012_PF-3758309_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K37764012_PF-3758309_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACBD3 acyl-CoA binding domain containing 3
ADCK3 aarF domain containing kinase 3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA5 annexin A5
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C2CD2 C2 calcium-dependent domain containing 2
CBR1 carbonyl reductase 1
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP1B charged multivesicular body protein 1B
CTSB cathepsin B
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPS8L2 EPS8-like 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM50A family with sequence similarity 50, member A
FOLR1 folate receptor 1 (adult)
FZD6 frizzled class receptor 6
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA1A heat shock 70kDa protein 1A
ILK integrin-linked kinase
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
KDM4B lysine (K)-specific demethylase 4B
KDM5D lysine (K)-specific demethylase 5D
LRP10 low density lipoprotein receptor-related protein 10
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MMP7 matrix metallopeptidase 7
NT5E 5'-nucleotidase, ecto (CD73)
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PLAT plasminogen activator, tissue
PLXNB2 plexin B2
POLB polymerase (DNA directed), beta
PRSS2 protease, serine, 2 (trypsin 2)
RBP4 retinol binding protein 4, plasma
RPS27L ribosomal protein S27-like
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SLC35E3 solute carrier family 35, member E3
SPATA20 spermatogenesis associated 20
STC1 stanniocalcin 1
STOM stomatin
STXBP2 syntaxin binding protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
VCAM1 vascular cell adhesion molecule 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA1 annexin A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
ATAD2 ATPase family, AAA domain containing 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CAT catalase
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDT1 chromatin licensing and DNA replication factor 1
CFH complement factor H
CHEK2 checkpoint kinase 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DCK deoxycytidine kinase
DCN decorin
DIO2 deiodinase, iodothyronine, type II
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DMXL2 Dmx-like 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DUT deoxyuridine triphosphatase
EREG epiregulin
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KLK11 kallikrein-related peptidase 11
LMNB1 lamin B1
LTF lactotransferrin
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MGP matrix Gla protein
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTA1 metastasis associated 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG2 non-SMC condensin II complex, subunit G2
NOV nephroblastoma overexpressed
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP85 nucleoporin 85kDa
PIP prolactin-induced protein
PLK1 polo-like kinase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RCC1 regulator of chromosome condensation 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMC4 structural maintenance of chromosomes 4
SOX11 SRY (sex determining region Y)-box 11
SPP1 secreted phosphoprotein 1
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
USP1 ubiquitin specific peptidase 1
VCAN versican
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein