BRD-K37764012_PF-3758309_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K37764012_PF-3758309_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT9 acyl-CoA thioesterase 9
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
BEX1 brain expressed, X-linked 1
CCDC92 coiled-coil domain containing 92
CCND1 cyclin D1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLDN10 claudin 10
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CTSA cathepsin A
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP1 dual specificity phosphatase 1
EPHA3 EPH receptor A3
FGG fibrinogen gamma chain
FXYD2 FXYD domain containing ion transport regulator 2
GAA glucosidase, alpha; acid
GPX1 glutathione peroxidase 1
H1F0 H1 histone family, member 0
HIST1H2BD histone cluster 1, H2bd
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IL6ST interleukin 6 signal transducer
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KCTD5 potassium channel tetramerization domain containing 5
LTBP1 latent transforming growth factor beta binding protein 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MET MET proto-oncogene, receptor tyrosine kinase
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
PDLIM5 PDZ and LIM domain 5
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PON2 paraoxonase 2
RAB4A RAB4A, member RAS oncogene family
RBKS ribokinase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCAND1 SCAN domain containing 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
TAC1 tachykinin, precursor 1
TCEAL4 transcription elongation factor A (SII)-like 4
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
UBE3B ubiquitin protein ligase E3B
XK X-linked Kx blood group

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
BIRC5 baculoviral IAP repeat containing 5
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD24 CD24 molecule
CD83 CD83 molecule
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
CLC Charcot-Leyden crystal galectin
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CTSH cathepsin H
CTSK cathepsin K
DCLK1 doublecortin-like kinase 1
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EHF ets homologous factor
ESRP1 epithelial splicing regulatory protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPNMB glycoprotein (transmembrane) nmb
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HOXB6 homeobox B6
HOXB7 homeobox B7
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JCHAIN joining chain of multimeric IgA and IgM
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KLK11 kallikrein-related peptidase 11
LMNB1 lamin B1
LTF lactotransferrin
LYZ lysozyme
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MNDA myeloid cell nuclear differentiation antigen
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NOP56 NOP56 ribonucleoprotein
OLFM4 olfactomedin 4
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PLAUR plasminogen activator, urokinase receptor
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSD3 pleckstrin and Sec7 domain containing 3
PYCR1 pyrroline-5-carboxylate reductase 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SF3A2 splicing factor 3a, subunit 2, 66kDa
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLBP stem-loop binding protein
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TK1 thymidine kinase 1, soluble
TMEM100 transmembrane protein 100
TMEM30B transmembrane protein 30B
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein