BRD-K37764012_PF-3758309_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K37764012_PF-3758309_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG2 adhesion G protein-coupled receptor G2
AREG amphiregulin
ATP9A ATPase, class II, type 9A
BPHL biphenyl hydrolase-like (serine hydrolase)
BTBD3 BTB (POZ) domain containing 3
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CPT1A carnitine palmitoyltransferase 1A (liver)
DSP desmoplakin
EPS8 epidermal growth factor receptor pathway substrate 8
GMDS GDP-mannose 4,6-dehydratase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GSTP1 glutathione S-transferase pi 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-A major histocompatibility complex, class I, A
HLA-C major histocompatibility complex, class I, C
HOPX HOP homeobox
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JAK1 Janus kinase 1
LRRC41 leucine rich repeat containing 41
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
NEBL nebulette
NPR3 natriuretic peptide receptor 3
NQO2 NAD(P)H dehydrogenase, quinone 2
PI3 peptidase inhibitor 3, skin-derived
PURA purine-rich element binding protein A
QPCT glutaminyl-peptide cyclotransferase
RRAGD Ras-related GTP binding D
S100A7 S100 calcium binding protein A7
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORBS1 sorbin and SH3 domain containing 1
STOM stomatin
STXBP1 syntaxin binding protein 1
SYNM synemin, intermediate filament protein
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ALOX5 arachidonate 5-lipoxygenase
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX2 armadillo repeat containing, X-linked 2
C3 complement component 3
CA1 carbonic anhydrase I
CCL2 chemokine (C-C motif) ligand 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFB complement factor B
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
EVI2A ecotropic viral integration site 2A
F3 coagulation factor III (thromboplastin, tissue factor)
FAM198B family with sequence similarity 198, member B
FCGBP Fc fragment of IgG binding protein
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGL2 fibrinogen-like 2
FN1 fibronectin 1
GLRX glutaredoxin (thioltransferase)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPG lipase, endothelial
LOX lysyl oxidase
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MNDA myeloid cell nuclear differentiation antigen
MOK MOK protein kinase
MRPL19 mitochondrial ribosomal protein L19
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAX8 paired box 8
PHGDH phosphoglycerate dehydrogenase
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POU2AF1 POU class 2 associating factor 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RTN2 reticulon 2
S100A1 S100 calcium binding protein A1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SEC24D SEC24 family member D
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2