BRD-K37764012_PF-3758309_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K37764012_PF-3758309_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AQP1 aquaporin 1 (Colton blood group)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COBL cordon-bleu WH2 repeat protein
CYFIP2 cytoplasmic FMR1 interacting protein 2
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
EFNB2 ephrin-B2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8 epidermal growth factor receptor pathway substrate 8
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDS iduronate 2-sulfatase
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LIMCH1 LIM and calponin homology domains 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MGST3 microsomal glutathione S-transferase 3
MXI1 MAX interactor 1, dimerization protein
NNMT nicotinamide N-methyltransferase
NR1H2 nuclear receptor subfamily 1, group H, member 2
PBX3 pre-B-cell leukemia homeobox 3
PKP2 plakophilin 2
PLA2G16 phospholipase A2, group XVI
POSTN periostin, osteoblast specific factor
RAP1GAP2 RAP1 GTPase activating protein 2
RPS27L ribosomal protein S27-like
RRAD Ras-related associated with diabetes
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMYD2 SET and MYND domain containing 2
SOX9 SRY (sex determining region Y)-box 9
TAGLN transgelin
TCTN1 tectonic family member 1
TGM2 transglutaminase 2
TP53 tumor protein p53
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1
WDTC1 WD and tetratricopeptide repeats 1
ZMAT3 zinc finger, matrin-type 3
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BCHE butyrylcholinesterase
CD24 CD24 molecule
CDC20 cell division cycle 20
CLC Charcot-Leyden crystal galectin
CRELD2 cysteine-rich with EGF-like domains 2
CRTAP cartilage associated protein
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DCN decorin
DPT dermatopontin
EBP emopamil binding protein (sterol isomerase)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBLN1 fibulin 1
FKBP11 FK506 binding protein 11, 19 kDa
FUS FUS RNA binding protein
HIST1H4C histone cluster 1, H4c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM3 interferon induced transmembrane protein 3
IGL immunoglobulin lambda locus
IQGAP1 IQ motif containing GTPase activating protein 1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
LAMB1 laminin, beta 1
LBR lamin B receptor
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL19 mitochondrial ribosomal protein L19
NPM3 nucleophosmin/nucleoplasmin 3
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD23B RAD23 homolog B (S. cerevisiae)
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
STMN1 stathmin 1
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VGLL4 vestigial-like family member 4