BRD-K37687095_AZD-8330_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AKR1C2 aldo-keto reductase family 1, member C2
ANXA4 annexin A4
C2CD2 C2 calcium-dependent domain containing 2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
DEPTOR DEP domain containing MTOR-interacting protein
FBLN1 fibulin 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA2 heat shock 70kDa protein 2
IL1R1 interleukin 1 receptor, type I
KDM5D lysine (K)-specific demethylase 5D
METTL7A methyltransferase like 7A
NARFL nuclear prelamin A recognition factor-like
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB1 SATB homeobox 1
SCD5 stearoyl-CoA desaturase 5
SERINC5 serine incorporator 5
SPINK1 serine peptidase inhibitor, Kazal type 1
STXBP6 syntaxin binding protein 6 (amisyn)
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSPAN7 tetraspanin 7
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCND1 cyclin D1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EREG epiregulin
FOSL1 FOS-like antigen 1
GPX1 glutathione peroxidase 1
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS1 lectin, galactoside-binding, soluble, 1
MCAM melanoma cell adhesion molecule
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLA2G16 phospholipase A2, group XVI
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RRM2 ribonucleotide reductase M2
SFTPB surfactant protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STX1A syntaxin 1A (brain)
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1