BRD-K37687095_AZD-8330_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
FBN2 fibrillin 2
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
HMG20B high mobility group 20B
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
JCHAIN joining chain of multimeric IgA and IgM
LDOC1 leucine zipper, down-regulated in cancer 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MXRA5 matrix-remodelling associated 5
NXN nucleoredoxin
ORAI3 ORAI calcium release-activated calcium modulator 3
PDGFD platelet derived growth factor D
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRAME preferentially expressed antigen in melanoma
RHOQ ras homolog family member Q
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TPM1 tropomyosin 1 (alpha)
TTC28 tetratricopeptide repeat domain 28
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
AURKB aurora kinase B
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CENPU centromere protein U
CHN2 chimerin 2
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EFHD2 EF-hand domain family, member D2
EREG epiregulin
ETV5 ets variant 5
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL13RA2 interleukin 13 receptor, alpha 2
LIG1 ligase I, DNA, ATP-dependent
MAMLD1 mastermind-like domain containing 1
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV3 neuron navigator 3
PARP2 poly (ADP-ribose) polymerase 2
PLAC8 placenta-specific 8
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8