BRD-K37687095_AZD-8330_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BTG1 B-cell translocation gene 1, anti-proliferative
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC3 chloride intracellular channel 3
COL11A1 collagen, type XI, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
EMP2 epithelial membrane protein 2
FGFR3 fibroblast growth factor receptor 3
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GREM1 gremlin 1, DAN family BMP antagonist
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITM2C integral membrane protein 2C
KIF5C kinesin family member 5C
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MFAP3L microfibrillar-associated protein 3-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDZRN3 PDZ domain containing ring finger 3
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
SESN1 sestrin 1
SMAD6 SMAD family member 6
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TYRP1 tyrosinase-related protein 1
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CCND1 cyclin D1
CD24 CD24 molecule
CST3 cystatin C
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HBEGF heparin-binding EGF-like growth factor
HHEX hematopoietically expressed homeobox
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IL1RN interleukin 1 receptor antagonist
JADE2 jade family PHD finger 2
JAG1 jagged 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LXN latexin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBOAT7 membrane bound O-acyltransferase domain containing 7
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NET1 neuroepithelial cell transforming 1
NNMT nicotinamide N-methyltransferase
PDLIM4 PDZ and LIM domain 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PTPRE protein tyrosine phosphatase, receptor type, E
SDC4 syndecan 4
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZFP36L1 ZFP36 ring finger protein-like 1