BRD-K37687095_AZD-8330_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

294 genes differentially expressed following the BRD-K37687095_AZD-8330_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ACSF2 acyl-CoA synthetase family member 2
ADD3 adducin 3 (gamma)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP9A ATPase, class II, type 9A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CADM1 cell adhesion molecule 1
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF2 CUGBP, Elav-like family member 2
CEP70 centrosomal protein 70kDa
CFB complement factor B
CFI complement factor I
CLIC5 chloride intracellular channel 5
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACH1 dachshund family transcription factor 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
EMX2 empty spiracles homeobox 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHB2 EPH receptor B2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FAM107A family with sequence similarity 107, member A
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GRAMD3 GRAM domain containing 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LIMK2 LIM domain kinase 2
LXN latexin
LZTFL1 leucine zipper transcription factor-like 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
METTL7A methyltransferase like 7A
MID1 midline 1
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
NDRG1 N-myc downstream regulated 1
NME5 NME/NM23 family member 5
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NPC2 Niemann-Pick disease, type C2
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PALLD palladin, cytoskeletal associated protein
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PROM1 prominin 1
PROS1 protein S (alpha)
PRR15L proline rich 15-like
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAB29 RAB29, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
REEP1 receptor accessory protein 1
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNX2 sorting nexin 2
SOX4 SRY (sex determining region Y)-box 4
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
SYNGR1 synaptogyrin 1
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCRB ubiquinol-cytochrome c reductase binding protein
VEGFA vascular endothelial growth factor A
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WBP1L WW domain binding protein 1-like
WDR45 WD repeat domain 45
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB10 zinc finger and BTB domain containing 10
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADORA2B adenosine A2b receptor
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BYSL bystin-like
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL9 chemokine (C-X-C motif) ligand 9
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EREG epiregulin
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FST follistatin
GAL galanin/GMAP prepropeptide
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GEMIN4 gem (nuclear organelle) associated protein 4
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KRT13 keratin 13, type I
KRT18 keratin 18, type I
LBR lamin B receptor
LDHA lactate dehydrogenase A
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAPG non-SMC condensin I complex, subunit G
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PFAS phosphoribosylformylglycinamidine synthase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PRMT5 protein arginine methyltransferase 5
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPINK5 serine peptidase inhibitor, Kazal type 5
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TMX2 thioredoxin-related transmembrane protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein