BRD-K37687095_AZD-8330_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-K37687095_AZD-8330_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
ADH6 alcohol dehydrogenase 6 (class V)
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAD aminolevulinate dehydratase
ANXA4 annexin A4
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C5 complement component 5
CAT catalase
CCNG2 cyclin G2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHL1 cell adhesion molecule L1-like
CLDN8 claudin 8
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYAB crystallin, alpha B
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCAF6 DDB1 and CUL4 associated factor 6
DDAH2 dimethylarginine dimethylaminohydrolase 2
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
EBP emopamil binding protein (sterol isomerase)
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM63A family with sequence similarity 63, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
GAS1 growth arrest-specific 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GOLGA8H golgin A8 family, member H
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HDAC6 histone deacetylase 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLHDC2 kelch domain containing 2
KYNU kynureninase
LBH limb bud and heart development
LMBRD1 LMBR1 domain containing 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LSP1 lymphocyte-specific protein 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6D lymphocyte antigen 6 complex, locus D
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K6 mitogen-activated protein kinase kinase 6
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NBR1 neighbor of BRCA1 gene 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMRK1 nicotinamide riboside kinase 1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
NYNRIN NYN domain and retroviral integrase containing
OPN3 opsin 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PAH phenylalanine hydroxylase
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC1 proline-rich nuclear receptor coactivator 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
QKI QKI, KH domain containing, RNA binding
QPRT quinolinate phosphoribosyltransferase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RXRA retinoid X receptor, alpha
SCGB1D2 secretoglobin, family 1D, member 2
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SNN stannin
SOX11 SRY (sex determining region Y)-box 11
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TF transferrin
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
TYRP1 tyrosinase-related protein 1
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
BMP4 bone morphogenetic protein 4
CALU calumenin
CCDC86 coiled-coil domain containing 86
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CD9 CD9 molecule
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMIP cell migration inducing protein, hyaluronan binding
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA2 EPH receptor A2
EREG epiregulin
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM3C family with sequence similarity 3, member C
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FRY furry homolog (Drosophila)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT1 G1 to S phase transition 1
GYG1 glycogenin 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGKV4-1 immunoglobulin kappa variable 4-1
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
JAG1 jagged 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT18 keratin 18, type I
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L3 nuclear factor, erythroid 2-like 3
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
ODC1 ornithine decarboxylase 1
PDAP1 PDGFA associated protein 1
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PRNP prion protein
RAB5C RAB5C, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A6 S100 calcium binding protein A6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN4 tetraspanin 4
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
VCAN versican
WARS tryptophanyl-tRNA synthetase
WDR3 WD repeat domain 3
YBX3 Y box binding protein 3
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing