BRD-K37687095_AZD-8330_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

291 genes differentially expressed following the BRD-K37687095_AZD-8330_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ARMCX3 armadillo repeat containing, X-linked 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AUH AU RNA binding protein/enoyl-CoA hydratase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CAT catalase
CCNG2 cyclin G2
CD163 CD163 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
COL11A1 collagen, type XI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FAM134B family with sequence similarity 134, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGB fibrinogen beta chain
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FXYD2 FXYD domain containing ion transport regulator 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GLS glutaminase
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
JUP junction plakoglobin
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLHL24 kelch-like family member 24
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LCN2 lipocalin 2
LRRC16A leucine rich repeat containing 16A
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
N4BP2L2 NEDD4 binding protein 2-like 2
NCK1 NCK adaptor protein 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NFE2L1 nuclear factor, erythroid 2-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH1 notch 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PENK proenkephalin
PERP PERP, TP53 apoptosis effector
PI3 peptidase inhibitor 3, skin-derived
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLIN2 perilipin 2
PPL periplakin
PROM1 prominin 1
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RAB9A RAB9A, member RAS oncogene family
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIDT2 SID1 transmembrane family, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYT1 synaptotagmin I
TAGLN transgelin
TCTA T-cell leukemia translocation altered
TM7SF2 transmembrane 7 superfamily member 2
TMEM135 transmembrane protein 135
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TRIM29 tripartite motif containing 29
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VTCN1 V-set domain containing T cell activation inhibitor 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CSRP1 cysteine and glycine-rich protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EIF5 eukaryotic translation initiation factor 5
ETV1 ets variant 1
EXO1 exonuclease 1
EXOSC2 exosome component 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
LMNB1 lamin B1
LMNB2 lamin B2
LPAR1 lysophosphatidic acid receptor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAMLD1 mastermind-like domain containing 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRGN neurogranin (protein kinase C substrate, RC3)
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHC2 polyhomeotic homolog 2 (Drosophila)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF4 pre-mRNA processing factor 4
PSRC1 proline/serine-rich coiled-coil 1
RACGAP1 Rac GTPase activating protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIVA1 SIVA1, apoptosis-inducing factor
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPK1 SRSF protein kinase 1
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP1 ubiquitin specific peptidase 1
WARS tryptophanyl-tRNA synthetase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein