BRD-K37687095_AZD-8330_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K37687095_AZD-8330_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATXN1 ataxin 1
AUTS2 autism susceptibility candidate 2
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
BGN biglycan
CALB1 calbindin 1, 28kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
DEPTOR DEP domain containing MTOR-interacting protein
EDN1 endothelin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR2 fibroblast growth factor receptor 2
GAGE3 G antigen 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ICAM1 intercellular adhesion molecule 1
IL32 interleukin 32
KRT8 keratin 8, type II
MPPED2 metallophosphoesterase domain containing 2
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NOTCH3 notch 3
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PDZK1 PDZ domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
RAB25 RAB25, member RAS oncogene family
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC22D3 TSC22 domain family, member 3
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WDR7 WD repeat domain 7
WFDC1 WAP four-disulfide core domain 1
ZBTB16 zinc finger and BTB domain containing 16
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C20ORF24 chromosome 20 open reading frame 24
CCND1 cyclin D1
CKS2 CDC28 protein kinase regulatory subunit 2
CPA3 carboxypeptidase A3 (mast cell)
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPI glucose-6-phosphate isomerase
GSPT2 G1 to S phase transition 2
HMOX2 heme oxygenase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
QDPR quinoid dihydropteridine reductase
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TBX3 T-box 3
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM147 transmembrane protein 147
TUBB6 tubulin, beta 6 class V
ZNF302 zinc finger protein 302
ZNF586 zinc finger protein 586