BRD-K37456065_VU0365114-2_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K37456065_VU0365114-2_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD24 CD24 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP170 centrosomal protein 170kDa
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLDN4 claudin 4
CSRP1 cysteine and glycine-rich protein 1
CST6 cystatin E/M
CTSB cathepsin B
DRAM1 DNA-damage regulated autophagy modulator 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESRP1 epithelial splicing regulatory protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HOMER3 homer scaffolding protein 3
HOPX HOP homeobox
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IDS iduronate 2-sulfatase
INHBA inhibin, beta A
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MAST2 microtubule associated serine/threonine kinase 2
MBP myelin basic protein
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MMP7 matrix metallopeptidase 7
NKX2-1 NK2 homeobox 1
PAWR PRKC, apoptosis, WT1, regulator
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRNP prion protein
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SLC43A3 solute carrier family 43, member 3
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK26 serine/threonine protein kinase 26
STX3 syntaxin 3
TACSTD2 tumor-associated calcium signal transducer 2
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D2 TSC22 domain family, member 2
VAT1 vesicle amine transport 1
WSB2 WD repeat and SOCS box containing 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
BMP4 bone morphogenetic protein 4
C3 complement component 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD40 CD40 molecule, TNF receptor superfamily member 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFI complement factor I
CLGN calmegin
CPE carboxypeptidase E
CSAD cysteine sulfinic acid decarboxylase
FCGBP Fc fragment of IgG binding protein
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
IFI44 interferon-induced protein 44
IFITM1 interferon induced transmembrane protein 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITM2A integral membrane protein 2A
LAP3 leucine aminopeptidase 3
LEF1 lymphoid enhancer-binding factor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MEIS2 Meis homeobox 2
MLEC malectin
MPPED2 metallophosphoesterase domain containing 2
NPTX2 neuronal pentraxin II
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZD2 PDZ domain containing 2
PDZK1 PDZ domain containing 1
PRDX2 peroxiredoxin 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFS1 Wolfram syndrome 1 (wolframin)