BRD-K37456065_VU0365114-2_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-K37456065_VU0365114-2_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANGPTL2 angiopoietin-like 2
ANGPTL4 angiopoietin-like 4
ARG2 arginase 2
ATF3 activating transcription factor 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
CCND2 cyclin D2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLC Charcot-Leyden crystal galectin
COLEC12 collectin sub-family member 12
CORO1A coronin, actin binding protein, 1A
CRISP3 cysteine-rich secretory protein 3
CTSZ cathepsin Z
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP1 dual specificity phosphatase 1
ELANE elastase, neutrophil expressed
EZR ezrin
FAM107A family with sequence similarity 107, member A
FBN2 fibrillin 2
FGL2 fibrinogen-like 2
FLNC filamin C, gamma
FMOD fibromodulin
FST follistatin
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
HCAR3 hydroxycarboxylic acid receptor 3
HEPH hephaestin
HIRA histone cell cycle regulator
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL1RN interleukin 1 receptor antagonist
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC100286895 cell division cycle 27 homolog pseudogene
LRMP lymphoid-restricted membrane protein
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MUC2 mucin 2, oligomeric mucus/gel-forming
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
PAWR PRKC, apoptosis, WT1, regulator
PDIA3 protein disulfide isomerase family A, member 3
PDZK1IP1 PDZK1 interacting protein 1
PRKCB protein kinase C, beta
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RHOB ras homolog family member B
RHOH ras homolog family member H
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
TBL1X transducin (beta)-like 1X-linked
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNNT1 troponin T type 1 (skeletal, slow)
TP53I3 tumor protein p53 inducible protein 3
TPST2 tyrosylprotein sulfotransferase 2
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
WNT5B wingless-type MMTV integration site family, member 5B
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF423 zinc finger protein 423
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
ADI1 acireductone dioxygenase 1
AHR aryl hydrocarbon receptor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BET1 Bet1 golgi vesicular membrane trafficking protein
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB2 cyclin B2
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CETN3 centrin, EF-hand protein, 3
CFI complement factor I
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHMP4A charged multivesicular body protein 4A
CLINT1 clathrin interactor 1
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COMMD8 COMM domain containing 8
CRYZ crystallin, zeta (quinone reductase)
CSRP1 cysteine and glycine-rich protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DYNLT3 dynein, light chain, Tctex-type 3
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
ETV1 ets variant 1
FABP7 fatty acid binding protein 7, brain
FASTKD5 FAST kinase domains 5
FXYD2 FXYD domain containing ion transport regulator 2
FZD6 frizzled class receptor 6
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GNAS GNAS complex locus
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSPT2 G1 to S phase transition 2
GSTP1 glutathione S-transferase pi 1
GTPBP8 GTP-binding protein 8 (putative)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT81 keratin 81, type II
KYNU kynureninase
LACTB2 lactamase, beta 2
LAMB1 laminin, beta 1
LAMP2 lysosomal-associated membrane protein 2
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMS1 LIM and senescent cell antigen-like domains 1
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MFSD10 major facilitator superfamily domain containing 10
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO6 myosin VI
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NNT nicotinamide nucleotide transhydrogenase
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NSL1 NSL1, MIS12 kinetochore complex component
OAT ornithine aminotransferase
ORC6 origin recognition complex, subunit 6
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPA1 pyrophosphatase (inorganic) 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QDPR quinoid dihydropteridine reductase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RFK riboflavin kinase
RNF167 ring finger protein 167
RPL27A ribosomal protein L27a
RPN2 ribophorin II
RPS11 ribosomal protein S11
S100A13 S100 calcium binding protein A13
SCG2 secretogranin II
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC35A5 solute carrier family 35, member A5
SOAT1 sterol O-acyltransferase 1
SSFA2 sperm specific antigen 2
STX1A syntaxin 1A (brain)
SUB1 SUB1 homolog (S. cerevisiae)
TCAF1 TRPM8 channel-associated factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TM2D3 TM2 domain containing 3
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM1 translocation associated membrane protein 1
TSNAX translin-associated factor X
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WBP5 WW domain binding protein 5
WWTR1 WW domain containing transcription regulator 1