BRD-K37392901_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-K37392901_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AHI1 Abelson helper integration site 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AVPI1 arginine vasopressin-induced 1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CTH cystathionine gamma-lyase
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EAF2 ELL associated factor 2
EIF1 eukaryotic translation initiation factor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELANE elastase, neutrophil expressed
ELL2 elongation factor, RNA polymerase II, 2
EPAS1 endothelial PAS domain protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FNBP1L formin binding protein 1-like
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HRH1 histamine receptor H1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LEFTY1 left-right determination factor 1
LOC100505650 uncharacterized LOC100505650
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MED13 mediator complex subunit 13
MTF2 metal response element binding transcription factor 2
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH1 notch 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRC2 arginine/serine-rich coiled-coil 2
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
STAR steroidogenic acute regulatory protein
TES testin LIM domain protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE2B ubiquitin-conjugating enzyme E2B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
WBP5 WW domain binding protein 5
WT1 Wilms tumor 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
AIM1 absent in melanoma 1
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ATF5 activating transcription factor 5
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C3 complement component 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCDC109B coiled-coil domain containing 109B
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLIC3 chloride intracellular channel 3
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNPY3 canopy FGF signaling regulator 3
CYBA cytochrome b-245, alpha polypeptide
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DHRS1 dehydrogenase/reductase (SDR family) member 1
EFHD1 EF-hand domain family, member D1
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
F2R coagulation factor II (thrombin) receptor
FAM63A family with sequence similarity 63, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBP1 fructose-1,6-bisphosphatase 1
GATA3 GATA binding protein 3
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTM3 glutathione S-transferase mu 3 (brain)
GTF3A general transcription factor IIIA
HMGN3 high mobility group nucleosomal binding domain 3
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
KDM4B lysine (K)-specific demethylase 4B
KIAA0391 KIAA0391
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6E lymphocyte antigen 6 complex, locus E
MAN1C1 mannosidase, alpha, class 1C, member 1
MARCKSL1 MARCKS-like 1
MLEC malectin
MUC1 mucin 1, cell surface associated
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NAV2 neuron navigator 2
NREP neuronal regeneration related protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRR15L proline rich 15-like
PRSS23 protease, serine, 23
PSRC1 proline/serine-rich coiled-coil 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BGRL SH3 domain binding glutamate-rich protein like
SMYD2 SET and MYND domain containing 2
SNN stannin
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
TGM2 transglutaminase 2
THY1 Thy-1 cell surface antigen
TMEM164 transmembrane protein 164
TMEM243 transmembrane protein 243, mitochondrial
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
UBL3 ubiquitin-like 3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
WBP1L WW domain binding protein 1-like