BRD-K37392901_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

221 genes differentially expressed following the BRD-K37392901_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CAV1 caveolin 1, caveolae protein, 22kDa
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP1B charged multivesicular body protein 1B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CREB5 cAMP responsive element binding protein 5
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CTSL cathepsin L
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLK10 kallikrein-related peptidase 10
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED13 mediator complex subunit 13
MIR22HG MIR22 host gene
MMP11 matrix metallopeptidase 11
NAMPT nicotinamide phosphoribosyltransferase
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PEA15 phosphoprotein enriched in astrocytes 15
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RB1CC1 RB1-inducible coiled-coil 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SPAG9 sperm associated antigen 9
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
TACC2 transforming, acidic coiled-coil containing protein 2
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE2B ubiquitin-conjugating enzyme E2B
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ADGRE5 adhesion G protein-coupled receptor E5
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BHLHE41 basic helix-loop-helix family, member e41
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CENPA centromere protein A
CNPY2 canopy FGF signaling regulator 2
COASY CoA synthase
DENND2D DENN/MADD domain containing 2D
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EI24 etoposide induced 2.4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GATA2 GATA binding protein 2
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF20A kinesin family member 20A
LY6E lymphocyte antigen 6 complex, locus E
MLEC malectin
MSL1 male-specific lethal 1 homolog (Drosophila)
NPY neuropeptide Y
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
PEBP1 phosphatidylethanolamine binding protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QARS glutaminyl-tRNA synthetase
RAB40B RAB40B, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS11 ribosomal protein S11
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SF3B3 splicing factor 3b, subunit 3, 130kDa
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TMPRSS3 transmembrane protease, serine 3
TSPYL5 TSPY-like 5
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF185 zinc finger protein 185 (LIM domain)