BRD-K37392901_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K37392901_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
ARC activity-regulated cytoskeleton-associated protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
BRAP BRCA1 associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CERS6 ceramide synthase 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLC Charcot-Leyden crystal galectin
CLU clusterin
COL1A1 collagen, type I, alpha 1
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
DTNA dystrobrevin, alpha
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
EPRS glutamyl-prolyl-tRNA synthetase
ERBB2IP erbb2 interacting protein
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
FOXG1 forkhead box G1
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HBD hemoglobin, delta
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLD3 phospholipase D family, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAP1 small ArfGAP 1
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
TES testin LIM domain protein
TEX10 testis expressed 10
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBB ubiquitin B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZCCHC6 zinc finger, CCHC domain containing 6
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADGRG6 adhesion G protein-coupled receptor G6
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APMAP adipocyte plasma membrane associated protein
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
B3GNT1
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CKLF chemokine-like factor
CPNE1 copine I
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSC cathepsin C
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EPHA3 EPH receptor A3
ERLIN1 ER lipid raft associated 1
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOSC7 exosome component 7
FABP4 fatty acid binding protein 4, adipocyte
FUCA1 fucosidase, alpha-L- 1, tissue
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX1 glutathione peroxidase 1
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLHL9 kelch-like family member 9
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MLEC malectin
MOK MOK protein kinase
MPRIP myosin phosphatase Rho interacting protein
MSH6 mutS homolog 6
MXRA7 matrix-remodelling associated 7
NCAPD3 non-SMC condensin II complex, subunit D3
NFIB nuclear factor I/B
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PLN phospholamban
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAGA Ras-related GTP binding A
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SVIL supervillin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM223 transmembrane protein 223
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
UBE2C ubiquitin-conjugating enzyme E2C
WWTR1 WW domain containing transcription regulator 1
ZMYM3 zinc finger, MYM-type 3