BRD-K37150847_methyl (3-phenyl-1H-indazol-1-yl)acetate BRD-K37150847_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K37150847_methyl (3-phenyl-1H-indazol-1-yl)acetate BRD-K37150847_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CRIP2 cysteine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
ELANE elastase, neutrophil expressed
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPCAM epithelial cell adhesion molecule
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP6 fatty acid binding protein 6, ileal
FCGBP Fc fragment of IgG binding protein
GNLY granulysin
HEPH hephaestin
HOPX HOP homeobox
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IL1R2 interleukin 1 receptor, type II
INHBB inhibin, beta B
IPO13 importin 13
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
MGAM maltase-glucoamylase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYRF myelin regulatory factor
NCAM1 neural cell adhesion molecule 1
NFE2 nuclear factor, erythroid 2
PDZK1IP1 PDZK1 interacting protein 1
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PON3 paraoxonase 3
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRSS2 protease, serine, 2 (trypsin 2)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
TARP TCR gamma alternate reading frame protein
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF20 transmembrane 4 L six family member 20
TM4SF4 transmembrane 4 L six family member 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCY1 adenylate cyclase 1 (brain)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX2 armadillo repeat containing, X-linked 2
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CCL19 chemokine (C-C motif) ligand 19
CD9 CD9 molecule
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN3 centrin, EF-hand protein, 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHMP4A charged multivesicular body protein 4A
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNM1L dynamin 1-like
EBNA1BP2 EBNA1 binding protein 2
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
G0S2 G0/G1 switch 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPSM2 G-protein signaling modulator 2
GPX3 glutathione peroxidase 3
GSPT2 G1 to S phase transition 2
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOMER2 homer scaffolding protein 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRSP12 heat-responsive protein 12
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL1 immunoglobulin lambda-like polypeptide 1
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAP3 leucine aminopeptidase 3
LEFTY1 left-right determination factor 1
LYPLA1 lysophospholipase I
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MRPS30 mitochondrial ribosomal protein S30
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
NAV2 neuron navigator 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
OSBPL9 oxysterol binding protein-like 9
OXA1L oxidase (cytochrome c) assembly 1-like
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRKCI protein kinase C, iota
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES prostaglandin E synthase
RABGAP1 RAB GTPase activating protein 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SNX2 sorting nexin 2
SYBU syntabulin (syntaxin-interacting)
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI2 tissue factor pathway inhibitor 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
TSNAX translin-associated factor X
TXNDC9 thioredoxin domain containing 9
UBE3C ubiquitin protein ligase E3C
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
XPO7 exportin 7
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta