BRD-K37043259_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K37043259_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADGRE5 adhesion G protein-coupled receptor E5
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
ANXA4 annexin A4
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CORO1A coronin, actin binding protein, 1A
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FN1 fibronectin 1
FOXO4 forkhead box O4
FSD1 fibronectin type III and SPRY domain containing 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA2 heat shock 70kDa protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IL32 interleukin 32
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
LPIN1 lipin 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOSPD1 motile sperm domain containing 1
MSN moesin
MSX1 msh homeobox 1
MSX2 msh homeobox 2
MYO1B myosin IB
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
PAM peptidylglycine alpha-amidating monooxygenase
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PNMA2 paraneoplastic Ma antigen 2
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDCBP syndecan binding protein (syntenin)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STON1 stonin 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WISP2 WNT1 inducible signaling pathway protein 2
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATF5 activating transcription factor 5
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCNE2 cyclin E2
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPH2 DPH2 homolog (S. cerevisiae)
EED embryonic ectoderm development
FAM57A family with sequence similarity 57, member A
GINS2 GINS complex subunit 2 (Psf2 homolog)
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
KIF14 kinesin family member 14
KRT10 keratin 10, type I
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MEPCE methylphosphate capping enzyme
MRPS30 mitochondrial ribosomal protein S30
NAT10 N-acetyltransferase 10 (GCN5-related)
NDC1 NDC1 transmembrane nucleoporin
NIP7 NIP7, nucleolar pre-rRNA processing protein
NPM3 nucleophosmin/nucleoplasmin 3
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDCD2 programmed cell death 2
PLK1 polo-like kinase 1
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SAC3D1 SAC3 domain containing 1
SHCBP1 SHC SH2-domain binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC2 structural maintenance of chromosomes 2
TRIP6 thyroid hormone receptor interactor 6
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein