BRD-K37021324_2-(4-(5-chloro-2-(cyclopentyloxy)phenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-70_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K37021324_2-(4-(5-chloro-2-(cyclopentyloxy)phenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-70_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL4 adhesion G protein-coupled receptor L4
ADIRF adipogenesis regulatory factor
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
CA4 carbonic anhydrase IV
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD93 CD93 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CLEC2B C-type lectin domain family 2, member B
CORO1A coronin, actin binding protein, 1A
CRABP1 cellular retinoic acid binding protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPAS1 endothelial PAS domain protein 1
FAM107A family with sequence similarity 107, member A
FBXO11 F-box protein 11
GPM6B glycoprotein M6B
IGHM immunoglobulin heavy constant mu
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAPTM5 lysosomal protein transmembrane 5
MFAP5 microfibrillar associated protein 5
MT1M metallothionein 1M
NLRP2 NLR family, pyrin domain containing 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZD2 PDZ domain containing 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLVAP plasmalemma vesicle associated protein
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PVALB parvalbumin
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TPSAB1 tryptase alpha/beta 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACSL1 acyl-CoA synthetase long-chain family member 1
ANXA5 annexin A5
APLP2 amyloid beta (A4) precursor-like protein 2
C6ORF48 chromosome 6 open reading frame 48
CCL20 chemokine (C-C motif) ligand 20
COL4A5 collagen, type IV, alpha 5
CST3 cystatin C
CTSH cathepsin H
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLG5 discs, large homolog 5 (Drosophila)
DMXL2 Dmx-like 2
DSP desmoplakin
FAM134C family with sequence similarity 134, member C
FLNA filamin A, alpha
GSAP gamma-secretase activating protein
HSPA8 heat shock 70kDa protein 8
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KYNU kynureninase
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LYST lysosomal trafficking regulator
MGP matrix Gla protein
MSX1 msh homeobox 1
NREP neuronal regeneration related protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SET SET nuclear proto-oncogene
SMCO4 single-pass membrane protein with coiled-coil domains 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4