BRD-K36740062_GSK-1070916_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K36740062_GSK-1070916_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CST1 cystatin SN
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GSPT2 G1 to S phase transition 2
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
IGF1R insulin-like growth factor 1 receptor
MAMLD1 mastermind-like domain containing 1
MSRB2 methionine sulfoxide reductase B2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLAT plasminogen activator, tissue
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SMAD3 SMAD family member 3
SVIL supervillin
TCEAL4 transcription elongation factor A (SII)-like 4
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALR calreticulin
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLEC11A C-type lectin domain family 11, member A
COPS7A COP9 signalosome subunit 7A
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOXM1 forkhead box M1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPNMB glycoprotein (transmembrane) nmb
GRWD1 glutamate-rich WD repeat containing 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LTF lactotransferrin
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PLK1 polo-like kinase 1
PTN pleiotrophin
RGS1 regulator of G-protein signaling 1
SHCBP1 SHC SH2-domain binding protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)