BRD-K36740062_GSK-1070916_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K36740062_GSK-1070916_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL10A1 collagen, type X, alpha 1
CST1 cystatin SN
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP4 fatty acid binding protein 4, adipocyte
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HOMER1 homer scaffolding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LY6E lymphocyte antigen 6 complex, locus E
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
MMP7 matrix metallopeptidase 7
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCCB propionyl CoA carboxylase, beta polypeptide
PFKM phosphofructokinase, muscle
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
REEP5 receptor accessory protein 5
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS16 regulator of G-protein signaling 16
RPS27L ribosomal protein S27-like
RRAGD Ras-related GTP binding D
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SQSTM1 sequestosome 1
TFF1 trefoil factor 1
TOX3 TOX high mobility group box family member 3
TRIM22 tripartite motif containing 22
TUSC3 tumor suppressor candidate 3
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKR1C2 aldo-keto reductase family 1, member C2
ATP11B ATPase, class VI, type 11B
BZW2 basic leucine zipper and W2 domains 2
C1R complement component 1, r subcomponent
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLU clusterin
COL6A2 collagen, type VI, alpha 2
DHCR24 24-dehydrocholesterol reductase
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
ELN elastin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R2 interleukin 1 receptor, type II
IPO13 importin 13
JAG1 jagged 1
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP1 latent transforming growth factor beta binding protein 1
MAMLD1 mastermind-like domain containing 1
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
NPY neuropeptide Y
NR1H2 nuclear receptor subfamily 1, group H, member 2
PLTP phospholipid transfer protein
PPAP2B phosphatidic acid phosphatase type 2B
PXMP2 peroxisomal membrane protein 2, 22kDa
SCRG1 stimulator of chondrogenesis 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIAH2 siah E3 ubiquitin protein ligase 2
TLR4 toll-like receptor 4
TNS1 tensin 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB4B tubulin, beta 4B class IVb
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3