BRD-K36737713_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K36737713_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG2 BCL2-associated athanogene 2
BRD2 bromodomain containing 2
CD58 CD58 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EMP1 epithelial membrane protein 1
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF4 Kruppel-like factor 4 (gut)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDE4DIP phosphodiesterase 4D interacting protein
PGD phosphogluconate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIR pirin (iron-binding nuclear protein)
PLA1A phospholipase A1 member A
PLAC8 placenta-specific 8
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TALDO1 transaldolase 1
TMEM97 transmembrane protein 97
TNPO1 transportin 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
ASCL1 achaete-scute family bHLH transcription factor 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CLDN3 claudin 3
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DPYSL3 dihydropyrimidinase-like 3
FNBP1 formin binding protein 1
GSN gelsolin
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
IQGAP1 IQ motif containing GTPase activating protein 1
LGALS3 lectin, galactoside-binding, soluble, 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PEG10 paternally expressed 10
POSTN periostin, osteoblast specific factor
RAB31 RAB31, member RAS oncogene family
SELENBP1 selenium binding protein 1
SNX7 sorting nexin 7
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
TCF4 transcription factor 4
TNS1 tensin 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)