BRD-K36363294_I-BET151_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K36363294_I-BET151_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDOC aldolase C, fructose-bisphosphate
APMAP adipocyte plasma membrane associated protein
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASMTL acetylserotonin O-methyltransferase-like
BMP4 bone morphogenetic protein 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
DSG2 desmoglein 2
ENAH enabled homolog (Drosophila)
FNBP1 formin binding protein 1
FZD7 frizzled class receptor 7
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
IGFBP5 insulin-like growth factor binding protein 5
JARID2 jumonji, AT rich interactive domain 2
KIF1A kinesin family member 1A
LBH limb bud and heart development
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LRP4 low density lipoprotein receptor-related protein 4
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCKSL1 MARCKS-like 1
MEAF6 MYST/Esa1-associated factor 6
MEG3 maternally expressed 3 (non-protein coding)
METRN meteorin, glial cell differentiation regulator
MID1IP1 MID1 interacting protein 1
MTUS1 microtubule associated tumor suppressor 1
MXRA7 matrix-remodelling associated 7
NDRG1 N-myc downstream regulated 1
NPC2 Niemann-Pick disease, type C2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTCH1 patched 1
RAB40B RAB40B, member RAS oncogene family
RHOB ras homolog family member B
SDC4 syndecan 4
SEPT10 septin 10
SH3BGR SH3 domain binding glutamate-rich protein
SH3YL1 SH3 and SYLF domain containing 1
SMAD3 SMAD family member 3
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAR steroidogenic acute regulatory protein
STXBP1 syntaxin binding protein 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TNS1 tensin 1
TPST2 tyrosylprotein sulfotransferase 2
TRIM2 tripartite motif containing 2
VIM vimentin
ZDHHC11 zinc finger, DHHC-type containing 11
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG3 BTG family, member 3
C1ORF106 chromosome 1 open reading frame 106
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CAPN1 calpain 1, (mu/I) large subunit
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDK2 cyclin-dependent kinase 2
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDR1 discoidin domain receptor tyrosine kinase 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
GPNMB glycoprotein (transmembrane) nmb
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM3 intercellular adhesion molecule 3
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL17RB interleukin 17 receptor B
IL1RN interleukin 1 receptor antagonist
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MXRA5 matrix-remodelling associated 5
NREP neuronal regeneration related protein
NTS neurotensin
NUP50 nucleoporin 50kDa
PI3 peptidase inhibitor 3, skin-derived
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
RBBP8 retinoblastoma binding protein 8
S100A6 S100 calcium binding protein A6
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD1 SMAD family member 1
SNX10 sorting nexin 10
SPATS2L spermatogenesis associated, serine-rich 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON1 spondin 1, extracellular matrix protein
SPRR3 small proline-rich protein 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TGFB3 transforming growth factor, beta 3
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSPAN4 tetraspanin 4
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
ZWINT ZW10 interacting kinetochore protein