BRD-K36363294_I-BET151_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K36363294_I-BET151_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ALDOC aldolase C, fructose-bisphosphate
ANKRD36B ankyrin repeat domain 36B
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C11ORF71 chromosome 11 open reading frame 71
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DUSP14 dual specificity phosphatase 14
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FAM50A family with sequence similarity 50, member A
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HSPA1A heat shock 70kDa protein 1A
IDS iduronate 2-sulfatase
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA1033 KIAA1033
KLF10 Kruppel-like factor 10
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MIR22HG MIR22 host gene
MT1X metallothionein 1X
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
PALLD palladin, cytoskeletal associated protein
PCDH9 protocadherin 9
PHYH phytanoyl-CoA 2-hydroxylase
PLAU plasminogen activator, urokinase
PNKP polynucleotide kinase 3'-phosphatase
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
QPCT glutaminyl-peptide cyclotransferase
RB1CC1 RB1-inducible coiled-coil 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND1 SCAN domain containing 1
SCPEP1 serine carboxypeptidase 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
SUGCT succinyl-CoA:glutarate-CoA transferase
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM2 transmembrane protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ALCAM activated leukocyte cell adhesion molecule
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIN1 bridging integrator 1
C3 complement component 3
C7 complement component 7
CCNA2 cyclin A2
CCR7 chemokine (C-C motif) receptor 7
CD3EAP CD3e molecule, epsilon associated protein
CDC42 cell division cycle 42
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHEK2 checkpoint kinase 2
CPA3 carboxypeptidase A3 (mast cell)
CRYZ crystallin, zeta (quinone reductase)
CSRP1 cysteine and glycine-rich protein 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DPH2 DPH2 homolog (S. cerevisiae)
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFS embryonal Fyn-associated substrate
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOSL1 FOS-like antigen 1
GPM6A glycoprotein M6A
GRWD1 glutamate-rich WD repeat containing 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0020 KIAA0020
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCM2 minichromosome maintenance complex component 2
MFAP4 microfibrillar-associated protein 4
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYRF myelin regulatory factor
NME1 NME/NM23 nucleoside diphosphate kinase 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDIA3 protein disulfide isomerase family A, member 3
PDLIM1 PDZ and LIM domain 1
PEX11A peroxisomal biogenesis factor 11 alpha
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RCC1 regulator of chromosome condensation 1
RPIA ribose 5-phosphate isomerase A
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCEL sciellin
SEPT9 septin 9
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC35F2 solute carrier family 35, member F2
SPRR3 small proline-rich protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TCF21 transcription factor 21
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
XIST X inactive specific transcript (non-protein coding)
YME1L1 YME1-like 1 ATPase