BRD-K36363294_I-BET151_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K36363294_I-BET151_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
ADI1 acireductone dioxygenase 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BEX1 brain expressed, X-linked 1
C14ORF132 chromosome 14 open reading frame 132
CD9 CD9 molecule
CLGN calmegin
CPNE3 copine III
CSTB cystatin B (stefin B)
CTSA cathepsin A
CTSD cathepsin D
DUSP10 dual specificity phosphatase 10
ECM1 extracellular matrix protein 1
EHD3 EH-domain containing 3
ENO2 enolase 2 (gamma, neuronal)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FUCA1 fucosidase, alpha-L- 1, tissue
GPR137B G protein-coupled receptor 137B
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LAMP2 lysosomal-associated membrane protein 2
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
NQO1 NAD(P)H dehydrogenase, quinone 1
PELI1 pellino E3 ubiquitin protein ligase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAF2 PRA1 domain family, member 2
RAB4A RAB4A, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SOD1 superoxide dismutase 1, soluble
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
TMEM50A transmembrane protein 50A
TMEM8A transmembrane protein 8A
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AEBP1 AE binding protein 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AXL AXL receptor tyrosine kinase
BIRC5 baculoviral IAP repeat containing 5
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL15A1 collagen, type XV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CTSG cathepsin G
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL2 ELOVL fatty acid elongase 2
EPCAM epithelial cell adhesion molecule
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBL fibrillarin
FBLN1 fibulin 1
FBN2 fibrillin 2
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GGCT gamma-glutamylcyclotransferase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
HBEGF heparin-binding EGF-like growth factor
HMGB2 high mobility group box 2
HOPX HOP homeobox
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IL7R interleukin 7 receptor
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF14 kinesin family member 14
LMNB1 lamin B1
LOX lysyl oxidase
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NAV3 neuron navigator 3
NDRG2 NDRG family member 2
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
P3H2 prolyl 3-hydroxylase 2
PCNA proliferating cell nuclear antigen
PCOLCE procollagen C-endopeptidase enhancer
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SET SET nuclear proto-oncogene
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARCL1 SPARC-like 1 (hevin)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN transgelin
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNNC1 troponin C type 1 (slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRBC1 T cell receptor beta constant 1
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
UCK2 uridine-cytidine kinase 2
VCAN versican