BRD-K36363294_I-BET151_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K36363294_I-BET151_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AHCYL2 adenosylhomocysteinase-like 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARHGAP29 Rho GTPase activating protein 29
ASCL1 achaete-scute family bHLH transcription factor 1
BLNK B-cell linker
BTG2 BTG family, member 2
C9ORF16 chromosome 9 open reading frame 16
CALCA calcitonin-related polypeptide alpha
CCNG2 cyclin G2
CD302 CD302 molecule
CD36 CD36 molecule (thrombospondin receptor)
CPNE3 copine III
CRLF1 cytokine receptor-like factor 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
FHL1 four and a half LIM domains 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GEM GTP binding protein overexpressed in skeletal muscle
GNB5 guanine nucleotide binding protein (G protein), beta 5
GSTM3 glutathione S-transferase mu 3 (brain)
HEBP1 heme binding protein 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HOXA10 homeobox A10
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KIF2C kinesin family member 2C
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MEF2C myocyte enhancer factor 2C
MYO6 myosin VI
NCAM1 neural cell adhesion molecule 1
NCOA1 nuclear receptor coactivator 1
NFIB nuclear factor I/B
NID1 nidogen 1
ODC1 ornithine decarboxylase 1
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G16 phospholipase A2, group XVI
PNKP polynucleotide kinase 3'-phosphatase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRAF2 PRA1 domain family, member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCZ protein kinase C, zeta
QKI QKI, KH domain containing, RNA binding
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN3 reticulon 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STXBP1 syntaxin binding protein 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMC5 transmembrane channel-like 5
TNIK TRAF2 and NCK interacting kinase
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
VNN1 vanin 1

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG1 adhesion G protein-coupled receptor G1
AIM1 absent in melanoma 1
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AK4 adenylate kinase 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANGPT1 angiopoietin 1
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE41 basic helix-loop-helix family, member e41
BHMT betaine--homocysteine S-methyltransferase
BTG3 BTG family, member 3
C1ORF116 chromosome 1 open reading frame 116
CALB1 calbindin 1, 28kDa
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CD69 CD69 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CNN1 calponin 1, basic, smooth muscle
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CST1 cystatin SN
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYTH1 cytohesin 1
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EFS embryonal Fyn-associated substrate
EGF epidermal growth factor
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GSTO1 glutathione S-transferase omega 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL32 interleukin 32
JMJD6 jumonji domain containing 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MYL9 myosin, light chain 9, regulatory
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP3 nuclear receptor interacting protein 3
OLFML3 olfactomedin-like 3
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCR1 pyrroline-5-carboxylate reductase 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOBTB3 Rho-related BTB domain containing 3
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLAMF8 SLAM family member 8
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SORBS3 sorbin and SH3 domain containing 3
SPARCL1 SPARC-like 1 (hevin)
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS2 transmembrane protease, serine 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRBC1 T cell receptor beta constant 1
TSKU tsukushi, small leucine rich proteoglycan
TXNDC9 thioredoxin domain containing 9
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZMYND11 zinc finger, MYND-type containing 11