BRD-K36363294_I-BET151_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K36363294_I-BET151_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AUTS2 autism susceptibility candidate 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
MAN1A1 mannosidase, alpha, class 1A, member 1
NDNF neuron-derived neurotrophic factor
NID2 nidogen 2 (osteonidogen)
OSR2 odd-skipped related transciption factor 2
SMYD3 SET and MYND domain containing 3
TFRC transferrin receptor
TMEM30B transmembrane protein 30B
TPD52L1 tumor protein D52-like 1

decreased expression

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
BICC1 BicC family RNA binding protein 1
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL8 chemokine (C-X-C motif) ligand 8
EDN1 endothelin 1
FXYD2 FXYD domain containing ion transport regulator 2
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HOXA5 homeobox A5
HOXB7 homeobox B7
ITGB5 integrin, beta 5
KRT7 keratin 7, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
NRP1 neuropilin 1
PDZK1 PDZ domain containing 1
PPARG peroxisome proliferator-activated receptor gamma
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPRY2 sprouty homolog 2 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican