BRD-K36363294_I-BET151_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K36363294_I-BET151_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADCK3 aarF domain containing kinase 3
AHNAK2 AHNAK nucleoprotein 2
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C4BPA complement component 4 binding protein, alpha
CALCA calcitonin-related polypeptide alpha
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC85B coiled-coil domain containing 85B
CCND2 cyclin D2
CD24 CD24 molecule
CKM creatine kinase, muscle
CORO1A coronin, actin binding protein, 1A
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
EFNB2 ephrin-B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV1 ets variant 1
ETV5 ets variant 5
EZR ezrin
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
H2BFS H2B histone family, member S (pseudogene)
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IER5 immediate early response 5
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KIAA0226L KIAA0226-like
LBH limb bud and heart development
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MB myoglobin
MEF2C myocyte enhancer factor 2C
MVP major vault protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PLS1 plastin 1
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
SIK1 salt-inducible kinase 1
SSR4 signal sequence receptor, delta
STAR steroidogenic acute regulatory protein
STXBP1 syntaxin binding protein 1
SUSD6 sushi domain containing 6
TBL1X transducin (beta)-like 1X-linked
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TSPAN8 tetraspanin 8
TTN titin
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBE2S ubiquitin-conjugating enzyme E2S
VAT1 vesicle amine transport 1
VLDLR very low density lipoprotein receptor
ZFP36 ZFP36 ring finger protein
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACAA2 acetyl-CoA acyltransferase 2
ACTN1 actinin, alpha 1
ADCY1 adenylate cyclase 1 (brain)
ANPEP alanyl (membrane) aminopeptidase
BST2 bone marrow stromal cell antigen 2
CALB1 calbindin 1, 28kDa
CCNE2 cyclin E2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL14 chemokine (C-X-C motif) ligand 14
DAXX death-domain associated protein
FSD1 fibronectin type III and SPRY domain containing 1
FSTL1 follistatin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIPK2 homeodomain interacting protein kinase 2
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXB2 homeobox B2
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB1 heat shock 27kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IL17RB interleukin 17 receptor B
JADE2 jade family PHD finger 2
KRT18 keratin 18, type I
LPAR1 lysophosphatidic acid receptor 1
MDFIC MyoD family inhibitor domain containing
MECOM MDS1 and EVI1 complex locus
MFAP2 microfibrillar-associated protein 2
MOK MOK protein kinase
MPPED2 metallophosphoesterase domain containing 2
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
P3H2 prolyl 3-hydroxylase 2
PCOLCE procollagen C-endopeptidase enhancer
PDHX pyruvate dehydrogenase complex, component X
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
SCGB1D2 secretoglobin, family 1D, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNX10 sorting nexin 10
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STC2 stanniocalcin 2
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
USP34 ubiquitin specific peptidase 34
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2