BRD-K36354764_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K36354764_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
ELF5 E74-like factor 5 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LITAF lipopolysaccharide-induced TNF factor
LMNA lamin A/C
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NR0B1 nuclear receptor subfamily 0, group B, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPN3 opsin 3
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPAP2C phosphatidic acid phosphatase type 2C
PRNP prion protein
PSAP prosaposin
RAD23B RAD23 homolog B (S. cerevisiae)
S100P S100 calcium binding protein P
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR3 small proline-rich protein 3
TALDO1 transaldolase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
BCHE butyrylcholinesterase
DCK deoxycytidine kinase
ESR1 estrogen receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GTPBP8 GTP-binding protein 8 (putative)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H4C histone cluster 1, H4c
HOXA5 homeobox A5
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LAGE3 L antigen family, member 3
LAMP5 lysosomal-associated membrane protein family, member 5
MMP9 matrix metallopeptidase 9
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NRN1 neuritin 1
OAT ornithine aminotransferase
PRDX2 peroxiredoxin 2
PRR15L proline rich 15-like
RGS4 regulator of G-protein signaling 4
SEPP1 selenoprotein P, plasma, 1
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TBX2 T-box 2
TSPAN13 tetraspanin 13
ZMIZ1 zinc finger, MIZ-type containing 1