BRD-K36354764_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K36354764_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
BDNF brain-derived neurotrophic factor
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP4 dual specificity phosphatase 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
FTL ferritin, light polypeptide
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPR171 G protein-coupled receptor 171
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IQCG IQ motif containing G
KLHL21 kelch-like family member 21
KRT7 keratin 7, type II
KYNU kynureninase
LMO4 LIM domain only 4
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NKG7 natural killer cell granule protein 7
NPC2 Niemann-Pick disease, type C2
NQO2 NAD(P)H dehydrogenase, quinone 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTGES prostaglandin E synthase
RAP1GAP RAP1 GTPase activating protein
RHOF ras homolog family member F (in filopodia)
S100P S100 calcium binding protein P
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TGFBI transforming growth factor, beta-induced, 68kDa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
BCHE butyrylcholinesterase
C7 complement component 7
CALD1 caldesmon 1
CAST calpastatin
CHGB chromogranin B
CLDN3 claudin 3
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNB3 ephrin-B3
EMP2 epithelial membrane protein 2
ESR1 estrogen receptor 1
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FILIP1L filamin A interacting protein 1-like
FRZB frizzled-related protein
GJA1 gap junction protein, alpha 1, 43kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXB2 homeobox B2
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NSG1 neuron specific gene family member 1
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
RAB38 RAB38, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SALL2 spalt-like transcription factor 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SULF1 sulfatase 1
THBS2 thrombospondin 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMSB15B thymosin beta 15B
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
TXNDC9 thioredoxin domain containing 9
XBP1 X-box binding protein 1