BRD-K36354764_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K36354764_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD10 ankyrin repeat domain 10
ATF3 activating transcription factor 3
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BTN3A2 butyrophilin, subfamily 3, member A2
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CHIC2 cysteine-rich hydrophobic domain 2
CLTC clathrin, heavy chain (Hc)
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP2 dual specificity phosphatase 2
DUSP22 dual specificity phosphatase 22
EGR1 early growth response 1
EGR3 early growth response 3
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FMOD fibromodulin
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GSAP gamma-secretase activating protein
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IQCG IQ motif containing G
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGA6 integrin, alpha 6
KIAA0355 KIAA0355
KIFAP3 kinesin-associated protein 3
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE4DIP phosphodiesterase 4D interacting protein
PITX1 paired-like homeodomain 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKCH protein kinase C, eta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB4A RAB4A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
SATB2 SATB homeobox 2
SCPEP1 serine carboxypeptidase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STX1A syntaxin 1A (brain)
TIAM1 T-cell lymphoma invasion and metastasis 1
TSKU tsukushi, small leucine rich proteoglycan
TTN titin
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CD36 CD36 molecule (thrombospondin receptor)
CDC27 cell division cycle 27
DCK deoxycytidine kinase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
HOXC10 homeobox C10
HOXC6 homeobox C6
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
IQGAP1 IQ motif containing GTPase activating protein 1
JADE2 jade family PHD finger 2
LRRC16A leucine rich repeat containing 16A
LRRC41 leucine rich repeat containing 41
LYZ lysozyme
MAOA monoamine oxidase A
MPO myeloperoxidase
PIP prolactin-induced protein
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS13 regulator of G-protein signaling 13
RPS11 ribosomal protein S11
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SST somatostatin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TOP1 topoisomerase (DNA) I
WASF1 WAS protein family, member 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta